I don't know if it works much for fliers since the strength won't get the AV 12 models that are the big trouble makers. That and the twin linking of Autocannons with orders or Exterminators have a pretty decent chance of not only hitting with enough volume, but having the Strength to back it up.
That being said I have been taking 2 punishers in my 6th edition lists. Now that they can move and pump 32 shots per turn into a target each. I don't know if its just my luck or sheer stubbornness but these two do way way more than a pair of standard russes for me these days.